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Joint Research Center (JRC)
CMD IV Model

Fourth revision of the Carcinogens and Mutagens Directive Model

HealthOccupational safety and healthworkers’ protectionfight against cancer

Quality & Transparency

Quality

Model uncertainties

Models are by definition affected by uncertainties (in input data, input parameters, scenario definitions, etc.). Have the model uncertainties been quantified? Are uncertainties accounted for in your simulations?

yes
This cost-benefit analysis posed several challenges, including additional endpoints, number of workers exposed, the future trends, the available epidemiologic evidence, the discount rate. Despite these challenges, some of these parameters have been quantified.

    Sensitivity analysis

    Sensitivity analysis helps identifying the uncertain inputs mostly responsible for the uncertainty in the model responses. Has the model undergone sensitivity analysis?

    yes
    Sensitivity analysis has been performed for one substance by taking into consideration lower and higher costs than the main estimate.

      Have model results been published in peer-reviewed articles?

      no

        Has the model formally undergone scientific review by a panel of international experts?

        Please note that this does not refer to the cases when model results were validated by stakeholders.

        no

          Model validation

          Has model validation been done? Have model predictions been confronted with observed data (ex-post)?

          yes
          For benzene, a comparison between the estimation of past exposure with actual reported cases was performed. The model results were then discussed against the reported cases.

            Transparency

            To what extent do input data come from publicly available sources?

            This may include sources accessible upon subscription and/or payment

            Based on both publicly available and restricted-access sources

            Is the full model database as such available to external users?

            Whether or not it implies a specific procedure or a fee

            no
            The databases used have been mentioned in the different reports of the study commissioned by the Commission to support the fourth revision of the Carcinogens and Mutagens Directive 2004/37/EC

              Have model results been presented in publicly available reports?

              Note this excludes IA reports.

              no

              Have output datasets been made publicly available?

              Note this could also imply a specific procedure or a fee.

              no
              The costs and benefits related to the policy options identified by the Commission are available in the impact assessment report accompanying the legislative proposal aiming to amend for the fourth time the Carcinogens and Mutagens Directive 2004/37/EC

                Is there any user friendly interface presenting model results that is accessible to the public?

                For instance: Dashboard, interactive interfaces...

                no

                  Has the model been documented in a publicly available dedicated report or a manual?

                  Note this excludes IA reports.

                  no

                  Is there a dedicated public website where information about the model is provided?

                  no

                    Is the model code open-source?

                    no

                    Can the code be accessed upon request?

                    no